Author's response to reviews Title:Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy A retrospective study with comparator group Authors:

نویسندگان

  • Santiago R Leal-Noval
  • Manuel Casado
  • Victoria Arellano-Orden
  • Reginald Dusseck
  • Javier Bautista
  • Aurelio Cayuela
چکیده

Santiago R Leal-Noval ([email protected]) Manuel Casado ([email protected]) Victoria Arellano-Orden ([email protected]) Reginald Dusseck ([email protected]) Javier Bautista ([email protected]) Manuel Múñoz-Gómez ([email protected]) José Naranjo-Izurieta ([email protected]) Antonio M Puppo-Moreno ([email protected]) Aurelio Cayuela ([email protected])

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Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy: a retrospective study with comparator group

BACKGROUND This retrospective, single centre study was conducted to investigate the efficacy of fibrinogen concentrate (FBNc) in decreasing blood requirements and reaching optimal fibrinogen level, in non-trauma, massively transfused, bleeding patients with coagulopathy. METHODS Over a 3-years period, all patients for whom a massive transfusion protocol was activated and had received ≥ 4 unit...

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Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients....

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تاریخ انتشار 2014